Plugging drugs is an alternative method of drug use that utilizes rectal administration of drugs. It is not the most natural route for drug administration. Even so, inserting the drugs in the anus is a medically viable way for taking many drugs. They include aspirin, glycerin, laxatives etc. You can also call rectal drug use booty bumping.
What causes opioid-induced constipation (OIC)?
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If you put any drug or alcohol in your anus it will have a much greater effect. Your anus absorbs chemicals quickly and effects are greater because it bypasses all your natural filters. This being said you can't take as much as you would orally risking overdose. If you put on shot of liquor in anus you will get super drunk but even 2 or 3 shots could give you alcohol poisoning.
Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels , [Note 1] and flow into the body's circulatory system , which distributes the drug to the body's organs and bodily systems. A drug that is administered rectally will in general depending on the drug have a faster onset, higher bioavailability , shorter peak, and shorter duration than oral administration. In addition, the rectal route bypasses around two thirds of the first-pass metabolism as the rectum's venous drainage is two thirds systemic middle and inferior rectal vein and one third hepatic portal system superior rectal vein.
Jump to content. An anal fissure is a tear in the lining of the lower rectum anal canal that causes pain during bowel movements. Anal fissures don't lead to more serious problems. Most anal fissures heal with home treatment after a few days or weeks. These are called short-term acute anal fissures.